Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi
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چکیده
منابع مشابه
Sulfadoxine-pyrimethamine resistance in the rodent malaria parasite Plasmodium chabaudi.
We have studied resistance to sulfadoxine-pyrimethamine (S/P) in the rodent malaria parasite Plasmodium chabaudi. A stable S/P-resistant mutant, AS(50S/P), was selected by drug treatment of a clone, AS(PYR), already resistant to pyrimethamine. The sequences of the P. chabaudi dhfr and dhps genes were obtained and found to be identical in AS(50S/P) and AS(PYR), showing that resistance to S/P in ...
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The genetic control of susceptibility to two species of murine malarial parasites was investigated with recombinant inbred (RI) mouse strains as a model system. Initially, the nonlethal Plasmodium yoelii 17X strain was cloned by limiting dilution to minimize parasite variability. This cloned P. yoelii was used to infect C57BL and BALB/c mice, strains which are the progenitors of the CXB RI stra...
متن کاملT-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells.
Acute infections caused by the murine malarial parasite Plasmodium chabaudi adami are resolved by antibody-independent mechanisms of immunity. The fact that athymic nude mice developed high-grade unrelenting malaria and died when infected with this parasite suggested a significant role for T lymphocytes. Using adoptive transfer techniques, we demonstrated that spleen cells from either nonimmune...
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Important to malaria vaccine design is the phenomenon of "strain-specific" immunity. Using an accurate and sensitive assay of parasite genotype, real-time quantitative PCR, we have investigated protective immunity against mixed infections of genetically distinct cloned "strains" of the rodent malaria parasite Plasmodium chabaudi chabaudi in mice. Four strains of P. c. chabaudi, AS, AJ, AQ, and ...
متن کاملNitric oxide is neither necessary nor sufficient for resolution of Plasmodium chabaudi malaria in mice.
Malaria is a life-threatening re-emerging disease, yet it is still not clear how bloodstage malarial parasites are killed. Nitric oxide (NO), which has potent anti-microbial activity, may represent an important killing mechanism. The production of NO during descending Plasmodium chabaudi parasitemia, a period when parasites are killed by the immune response, supports this concept. However, NOS2...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1985
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.47.2.452-456.1985